The Center for Disease Control and Prevention (CDC) issued an advisory on Friday asking doctors across the United States to be on the watch for monkeypox, as the World Health Organization has confirmed 80 confirmed cases across 11 countries.

Monkeypox is a viral disease typically endemic to central and western Africa, but since the start of May, dozens of confirmed cases have been reported in several countries outside of the continent. Many more suspected cases are being investigated.

The CDC is asking doctors to “be vigilant to the characteristic rash associated with monkeypox” and describes the rash as involving “vesicles or pustules that are deep-seated, firm or hard, and well-circumscribed,” adding that the lesions “may umbilicate or become confluent and progress over time to scabs.”

It adds that doctors should be more suspicious for the disease and consider it as a possible diagnosis if, in addition to having a characteristic rash, their patient has traveled to countries with recently confirmed cases of monkeypox; reports having had contact with anyone who had monkeypox, or suspected monkeypox, or have a rash similar in appearance to monkeypox; or is a man who regularly has close or intimate in-person contact with other men.